COVID-19'un uzun dönem mortalitesinde C-reaktif protein/ albümin oranı ve sistemik immün inflamasyon indeksinin prediktif değeri
Öz
Amaç: Coronavirüs-19 hastalığının (COVID-19) kısa dönem prognozu ile biyobelirteçlerle ilgili bir çok çalışma yapılmıştır; ancak uzun dönem prognozu ile ilgili çalışmalar kısıtlıdır. Amacımız; sistemik inflamasyon indeksi (SII) ve C-reaktif protein/ albümin oranının (CAR) COVID-19 hastalığının hastane içi ve 1 yıllık takiplerinde prediktif değerini saptamaktır.
Gereç ve Yöntemler: Primer sonuçlar hastane içi mortalite ve 1 yıllık mortalite idi. İkincil sonuçlar; yatışta yoğun bakım ünitesi (YBÜ) ihtiyacı ve sonrasında YBÜ'ye transfer olma durumu idi.
Bulgular: Çalışmaya 449 (53.6 %) erkek ve 389 ( 46.4 %) kadın katıldı. Yaş ortalaması 53.8±18.5 idi. Önceden bilinen kalp yetmezliği (KY), COVID-19 ile ilişkili KY, akut böbrek yetmezliği (ABY), diyabetes mellitus (DM), hipertansiyon (HT), koroner arter hastalığı (KAH), kronik obstrüktif akciğer hastalığı (KOAH)/astım , yüksek CO-RADS skoru ( >4), düşük Ejeksiyon Fraksiyonu (EF), yüksek CAR ve SII, artmış hastane içi ve 1 yıllık mortalite ile ilişkilendirildi (p < 0.05). Çok değişkenli analiz sonucunda; CAR, SII, ABY ve DM hastane içi ve 1 yıllık mortalitenin bağımsız belirteçleri iken, KAH sadece 1 yıllık mortalitenin bağımsız bir öngörücüsüydü. ROC analizi ile sırasıyla 2.54 ve 2.23 CAR değerleri, hastane içi ve 1 yıllık mortaliteyi predikte etti (p <0.001). Sırasıyla 1274 ve 1191 SII değerleri, hastane içi ve 1 yıllık mortaliteyi predikte etti (p <0.001).
Sonuç: CAR ve SII, COVID-19’da hem kısa dönemde hem uzun dönemde mortaliteyi tahmin etmek için değerli prognostik indeksler olarak kullanılabilir.
Anahtar Kelimeler
Sistemik İmmün İnflamasyon İndeksi SII C-reaktif protein/albümin oranı CAR Uzun dönem mortalite COVID-19
Kaynakça
- Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association. Circulation 2021; 143: e254-743.
- Piombi-Adanza SN, Baretto MC, Echaide FA, et al. Analysis of oxygen blood saturation/respiratory rate index, NEWS2, CURB65, and quick sequential organ failure assessment scores to assess prognosis in patients with mild coronavirus disease 2019. Rev Invest Clin 2021; 73: 399-407.
- Inanc IH, Bursa N, Gultepe A, Bayramoğlu M, Sabanoglu C, Inanc FA. Association among CO-RADS score, co-morbid diseases, and short-term prognosis in COVID-19 infection. Eur Rev Med Pharmacol Sci 2022; 26: 653-63.
- Gaspar-Hernández J, Araiza-Garaygordobil D, Gopar-Nieto R, Martínez-Amezcua P, Arias-Mendoza A. impact of the coronavirus disease-19 pandemic on acute cardiovascular emergencies in a third level cardiology hospital: a call for action. Rev Invest Clin 2020; 72: 280-2.
- Ramos-Araque ME, Siegler JE, Ribo M, et al. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurol 2021; 21: 43.
- Inanc IH, Sabanoglu C. Autonomic dysfunction and metabolic disorders as the possible sequelae of COVID-19 infection. Eur Rev Med Pharmacol Sci 2022; 26: 5587-95.
- Saylik F, Akbulut T, Kaya S. Can c-reactive protein to albumin ratio predict in-hospital death rate due to COVID-19 in patients with hypertension? Angiology 2021; 72: 947-52.
- Fois AG, Paliogiannis P, Scano V, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules 2020; 25: 5725.
- Li Y, Li H, Song C, et al. Early prediction of disease progression in patients with severe COVID-19 using c-reactive protein to albumin ratio. Dis Markers 2021; 2021: 6304189.
- Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune- inflammation index in cancer: a meta-analysis. J Cancer 2018; 9: 3295-302.
- Ishizuka M, Nagata H, Takagi K, Iwasaki Y, Shibuya N, Kubota K. Clinical significance of the c-reactive protein to albumin ratio for survival after surgery for colorectal cancer. Ann Surg Oncol 2016;23:900-7.
- Özcan S, Dönmez E, Yavuz Tuğrul S, et al. The prognostic value of C-reactive protein/albumin ratio in acute pulmonary embolism. Rev Invest Clin 2022; 74: 97-103.
- Denegri A, Obeid S, Raeber L, et al. Systemic immune-inflammation index predicts major adverse cardiovascular events in patients with ST-elevation myocardial infarction. Eur Heart J 2021; 42: ehab724-1353.
- Prokop M, van Everdingen W, van Rees Vellinga T, et al. CO-RADS: a categorical CT assessment scheme for patients suspected of having COVID-19-definition and evaluation. Radiology 2020; 296: E97-104.
- Wiegers SE, Ryan T, Arrighi JA, et al. 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): a report of the ACC competency management committee. J Am Soc Echocardiogr 2019; 32: 919-43.
- Walle-Hansen MM, Ranhoff AH, Mellingsæter M, Wang-Hansen MS, Myrstad M. Health-related quality of life, functional decline, and long-term mortality in older patients following hospitalisation due to COVID-19. BMC Geriatr 2021; 21: 199.
- Di Bari M, Tonarelli F, Balzi D, et al. COVID-19, vulnerability, and long-term mortality in hospitalized and non-hospitalized older persons. J Am Med Dir Assoc 2022; 23: 414-20.
- Carriazo S, Mas-Fontao S, Seghers C, et al. Increased 1-year mortality in haemodialysis patients with COVID-19: a prospective, observational study. Clin Kidney J 2021; 15: 432-41.
- Sproston NR, Ashworth JJ. Role of c-reactive protein at sites of inflammation and infection. Front Immunol 2018; 9: 754.
- Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med 2018;52:8-12.
- Karadeniz M, Duran M, Akyel A, et al. High-sensitive CRP level is associated with intermediate and high Syntax score in patients with acute coronary syndrome. Int Heart J 2015; 56: 377-80.
- Lucijanić M, Stojić J, Atić A, et al. Clinical and prognostic significance of c-reactive protein to albumin ratio in hospitalized coronavirus disease 2019 (COVID-19) patients: data on 2309 patients from a tertiary center and validation in an independent cohort. Wien Klin Wochenschr 2022; 134: 377-84.
- Manne BK, Denorme F, Middleton EA, et al. Platelet gene expression and function in patients with COVID-19. Blood 2020; 136: 1317-29.
- Acar E, Demir A, Yıldırım B, Kaya MG, Gökçek K. The role of hemogram parameters and c-reactive protein in predicting mortality in COVID-19 infection. Int J Clin Pract 2021; 75: e14256.
- Kudlinski B, Zgoła D, Stolińska M, et al. Systemic inflammatory predictors of in-hospital mortality in COVID-19 patients: a retrospective study. Diagnostics (Basel) 2022; 12: 859.
- Ari A, Gunver F. Comparison of neutrophil-lymphocyte ratio and platelet- lymphocyte ratio in patients with thyroiditis and papillary tumors. J Int Med Res 2019; 47: 2077-83.
- Xue G, Gan X, Wu Z, et al. Novel serological biomarkers for inflammation in predicting disease severity in patients with COVID-19. Int Immunopharmacol 2020; 89: 107065.
Predictive value of c-reactive protein to albumin ratio and systemic immune-inflammation index for the long-term mortality in COVID-19
Öz
Aim: Several studies have investigated the association between biomarkers and short-term prognosis in the coronavirus infectious disease 2019 (COVID-19). However, data on the long-term prognosis are limited. To determine the predictive value of systemic immune-inflammation index (SII) and C-reactive protein (CRP) to albumin ratio (CAR) for in-hospital and 1-year outcomes during COVID-19.
Material and Method: The primary outcomes were in-hospital and 1-year mortality. The secondary outcomes were the intensive care unit (ICU) need at admission and transfer to the ICU later on.
Results: The study included 449 (53.6%) males and 389 (46.4%) females with a mean age of 53.8±18.5 years. Previously known heart failure (HF), COVID-19-related HF, acute renal failure (ARF), diabetes mellitus, hypertension, coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD)/asthma, high CO-RADS scores (>4), low ejection fraction (EF), higher CAR and SII were associated with an increased in-hospital and 1-year mortality (p<0.05). After multivariate analysis; CAR, SII, ARF, and diabetes mellitus were independent predictors of in-hospital and 1-year mortality,whereas CAD was only an independent predictor of 1-year mortality. After ROC analysis, CAR cut-off levels of 2.54 and 2.23 predicted in-hospital and 1-year mortality, respectively (p<0.001). The SII cut-off levels of 1274 and 1191 predicted in-hospital and 1-year mortality, respectively (p<0.001).
Conclusion: CAR and SII can be used as valuable prognostic indexes to predict both the short-term and long-term mortality in COVID-19.
Anahtar Kelimeler
Systemic immune-inflammation index SII C-reactive protein to albumin ratio CAR long-term mortality COVID-19
Kaynakça
- Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 update: a report from the American Heart Association. Circulation 2021; 143: e254-743.
- Piombi-Adanza SN, Baretto MC, Echaide FA, et al. Analysis of oxygen blood saturation/respiratory rate index, NEWS2, CURB65, and quick sequential organ failure assessment scores to assess prognosis in patients with mild coronavirus disease 2019. Rev Invest Clin 2021; 73: 399-407.
- Inanc IH, Bursa N, Gultepe A, Bayramoğlu M, Sabanoglu C, Inanc FA. Association among CO-RADS score, co-morbid diseases, and short-term prognosis in COVID-19 infection. Eur Rev Med Pharmacol Sci 2022; 26: 653-63.
- Gaspar-Hernández J, Araiza-Garaygordobil D, Gopar-Nieto R, Martínez-Amezcua P, Arias-Mendoza A. impact of the coronavirus disease-19 pandemic on acute cardiovascular emergencies in a third level cardiology hospital: a call for action. Rev Invest Clin 2020; 72: 280-2.
- Ramos-Araque ME, Siegler JE, Ribo M, et al. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurol 2021; 21: 43.
- Inanc IH, Sabanoglu C. Autonomic dysfunction and metabolic disorders as the possible sequelae of COVID-19 infection. Eur Rev Med Pharmacol Sci 2022; 26: 5587-95.
- Saylik F, Akbulut T, Kaya S. Can c-reactive protein to albumin ratio predict in-hospital death rate due to COVID-19 in patients with hypertension? Angiology 2021; 72: 947-52.
- Fois AG, Paliogiannis P, Scano V, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules 2020; 25: 5725.
- Li Y, Li H, Song C, et al. Early prediction of disease progression in patients with severe COVID-19 using c-reactive protein to albumin ratio. Dis Markers 2021; 2021: 6304189.
- Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune- inflammation index in cancer: a meta-analysis. J Cancer 2018; 9: 3295-302.
- Ishizuka M, Nagata H, Takagi K, Iwasaki Y, Shibuya N, Kubota K. Clinical significance of the c-reactive protein to albumin ratio for survival after surgery for colorectal cancer. Ann Surg Oncol 2016;23:900-7.
- Özcan S, Dönmez E, Yavuz Tuğrul S, et al. The prognostic value of C-reactive protein/albumin ratio in acute pulmonary embolism. Rev Invest Clin 2022; 74: 97-103.
- Denegri A, Obeid S, Raeber L, et al. Systemic immune-inflammation index predicts major adverse cardiovascular events in patients with ST-elevation myocardial infarction. Eur Heart J 2021; 42: ehab724-1353.
- Prokop M, van Everdingen W, van Rees Vellinga T, et al. CO-RADS: a categorical CT assessment scheme for patients suspected of having COVID-19-definition and evaluation. Radiology 2020; 296: E97-104.
- Wiegers SE, Ryan T, Arrighi JA, et al. 2019 ACC/AHA/ASE advanced training statement on echocardiography (revision of the 2003 ACC/AHA clinical competence statement on echocardiography): a report of the ACC competency management committee. J Am Soc Echocardiogr 2019; 32: 919-43.
- Walle-Hansen MM, Ranhoff AH, Mellingsæter M, Wang-Hansen MS, Myrstad M. Health-related quality of life, functional decline, and long-term mortality in older patients following hospitalisation due to COVID-19. BMC Geriatr 2021; 21: 199.
- Di Bari M, Tonarelli F, Balzi D, et al. COVID-19, vulnerability, and long-term mortality in hospitalized and non-hospitalized older persons. J Am Med Dir Assoc 2022; 23: 414-20.
- Carriazo S, Mas-Fontao S, Seghers C, et al. Increased 1-year mortality in haemodialysis patients with COVID-19: a prospective, observational study. Clin Kidney J 2021; 15: 432-41.
- Sproston NR, Ashworth JJ. Role of c-reactive protein at sites of inflammation and infection. Front Immunol 2018; 9: 754.
- Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med 2018;52:8-12.
- Karadeniz M, Duran M, Akyel A, et al. High-sensitive CRP level is associated with intermediate and high Syntax score in patients with acute coronary syndrome. Int Heart J 2015; 56: 377-80.
- Lucijanić M, Stojić J, Atić A, et al. Clinical and prognostic significance of c-reactive protein to albumin ratio in hospitalized coronavirus disease 2019 (COVID-19) patients: data on 2309 patients from a tertiary center and validation in an independent cohort. Wien Klin Wochenschr 2022; 134: 377-84.
- Manne BK, Denorme F, Middleton EA, et al. Platelet gene expression and function in patients with COVID-19. Blood 2020; 136: 1317-29.
- Acar E, Demir A, Yıldırım B, Kaya MG, Gökçek K. The role of hemogram parameters and c-reactive protein in predicting mortality in COVID-19 infection. Int J Clin Pract 2021; 75: e14256.
- Kudlinski B, Zgoła D, Stolińska M, et al. Systemic inflammatory predictors of in-hospital mortality in COVID-19 patients: a retrospective study. Diagnostics (Basel) 2022; 12: 859.
- Ari A, Gunver F. Comparison of neutrophil-lymphocyte ratio and platelet- lymphocyte ratio in patients with thyroiditis and papillary tumors. J Int Med Res 2019; 47: 2077-83.
- Xue G, Gan X, Wu Z, et al. Novel serological biomarkers for inflammation in predicting disease severity in patients with COVID-19. Int Immunopharmacol 2020; 89: 107065.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Research Articles [en] Araştırma Makaleleri [tr] |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Mart 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 4 Sayı: 2 |
Kaynak Göster
|
|
|
|
|
|
|
|
Dergimiz; TR-Dizin ULAKBİM, ICI World of Journal's, Index Copernicus, Directory of Research Journals Indexing (DRJI), General Impact Factor, Google Scholar, Researchgate, WorldCat (OCLC), CrossRef (DOI), ROAD, ASOS İndeks, Türk Medline İndeks, Eurasian Scientific Journal Index (ESJI) ve Türkiye Atıf Dizini'nde indekslenmektedir.
EBSCO, DOAJ, OAJI, ProQuest dizinlerine müracaat yapılmış olup, değerlendirme aşamasındadır.
Makaleler "Çift-Kör Hakem Değerlendirmesi”nden geçmektedir.
Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN].
Note: Our journal is not WOS indexed and therefore is not classified as Q.
You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. About predatory/questionable journals and journal charge policy
Not: Dergimiz WOS indeksli değildir ve bu nedenle Q sınıflamasına dahil değildir.
Yağmacı/şüpheli dergilerle ilgili Yüksek Öğretim Kurumu (YÖK) kararları ve yazar açıklama metni ile dergi ücret politikası: Yağmacı/Şaibeli Dergiler ve Dergi Ücret Politikası