The aim of the present study is to
develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for
release of Donepezil HCl for potential treatment of Alzheimer’s disease.
[2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure
184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure
2959) were used as photo-initiators in
the synthesis of hydrogels and
hydroxyapatite was used for modifying hydrogels. Fourier transform
infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital
microscope were utilized to investigate the characteristics properties of hydrogels.
Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have been
performed under different pH conditions.
Hydrogels Photopolymerization Donepezil HCl Polyethylene diacyrlate Alzheimer's Disease
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 15 Mayıs 2019 |
Gönderilme Tarihi | 20 Kasım 2018 |
Kabul Tarihi | 3 Ocak 2019 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 6 Sayı: 1 |